Cognitive and psychological dysfunction is present after a first seizure, prior to epilepsy diagnosis and treatment at a First Seizure Clinic.
Pugh et al. 2024
Presentation by Dr. Rohan Kandasamy
00:57 - Epilepsy and Comorbidities
2:28 - First Paper Overview:Â The study aimed to capture the neuropsychological profile of drug-naive new-onset epilepsy.
3:36 - Study Methodology:Â The study population included 32 individuals with epilepsy and 30 healthy controls.
5:42 - Cognitive and Psychological Assessments
8:15 - Study Results:Â The epilepsy group had deficits in verbal memory, working memory, and executive function.
9:16 - Discussion and Implications:Â Cognitive and psychological symptoms in epilepsy are primary effects of the disease rather than secondary effects of anti-seizure medications.
13:52 - Conclusion and Limitations:Â The study's design may have failed to exclude pre-existing psychological comorbidities and concurrent health-related anxiety.
Discussion
00:00 - Study Strengths and Weaknesses
01:00 - Seizure Events and Diagnosis
02:00 - Cognitive and Psychological Symptoms
03:00 - Methodology Concerns
05:00 - Telemedicine and Testing
07:00 - EEG and Cognitive Function
08:00 - Socioeconomic Status
09:00 - Summary of the Paper
Impact of Depressive Symptoms on Adverse Effects in People with Epilepsy on Antiseizure Medication Therapy
Panholzer et al. 2023
Presentation by Dr. Kamil Wezyk
00:58 - Introduction to Second Paper
02:53 - Study Objective: The study aimed to analyze the relationship between depressive symptoms and reported adverse effects of anti-seizure medication in people with epilepsy.
03:48 - Methodology:Â The study involved adult patients diagnosed with epilepsy and on long-term antiseizure medication therapy.
06:27 - Study Population:Â Most patients were diagnosed with focal epilepsy, and a significant portion were treated with monotherapy.
09:11 - Key Findings:Â The study found that depression significantly confounds adverse effects reporting in people with epilepsy on seizure medication therapy, affecting both emotional and somatic adverse effects.
10:13 - Study Limitations: The study had several limitations, including its cross-sectional design, reliance on self-reported measures, poorly defined inclusion criteria, and limited covariates in logistic regression.
14:30 - Conclusion and Implications: The study highlights the importance of considering depressive symptoms when evaluating adverse effects in people with epilepsy on anti-seizure medication therapy.
Discussion
00:00 - Study on Drug-Resistant Epilepsy
02:48 - Depression and Epilepsy
03:41 - Study Limitations
05:30 - Adverse Effects and Depression
11:38 - Choosing Anti-Seizure Medication
10:54 - Study Summary